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Earlier Grants

In October 2003 Cure JM Foundation began its mission to do whatever is necessary to help find a cure for juvenile myositis. Within a year, through the fundraising efforts of the JM community and many generous contributions, we were able to grant two important research fellowships.

In June, 2004, Cure JM awarded a fellowship to Dr. Gulnara Mamyrova, M.D., Ph.D, to complete the Childhood Myositis Heterogeneity Study and projects related to analysis of data from this registry study. This study was conducted under the guidance of Dr. Lisa Rider, M.D. by the Environmental Autoimmunity Group at NIEHS, National Institutes of Health. Deputy Chief Dr. Rider and Chief Dr. Frederick Miller, M.D., Ph.D. were the principal investigators of this study. Dr. Mamyrova’s fellowship funding began on November 25, 2004 and and continued until November 21, 2007. The total amount of this grant was $147,660.

Dr. Mamyrova’s research focused on identifying new immunogenetic risk factors for JM, studying specific complications of illness, such as lipodystrophy, and working on establishing the database and long term outcomes for several hundred patients enrolled in the Childhood Myositis Heterogeneity Study registry. Dr. Mamyrova has presented her work from this study at a number of national and regional meetings, including the American College of Rheumatology, the NIH Research Festival, and DC Rheumatism Society. She received recognition for her work on this study from the DC Rheumatism Society as a Poster Award Winner at their Fellows Forum.

Published papers:

  1. Mamyrova G, O’Hanlon TP, Monroe JB, Mercatante Carrick D, Malley JD, Adams S, Reed AM, Shamim EA, James-Newton L, Miller FW, Rider LG, for the Childhood Myositis Heterogeneity Collaborative Study Group. Immunogenetic risk and protective factors for juvenile dermatomyositis in Caucasians. Arthritis and Rheumatism. 2006; 54: 3979 – 3987.
  2. Mamyrova G, Kleiner DE, James-Newton L, Shaham B, Miller FW, Rider LG. Late-Onset Gastrointestinal Pain in Juvenile Dermatomyositis as a Manifestation of Ischemic Ulceration from Chronic Endarteropathy. Arthritis and Rheumatism (Arthritis Care and Research). 2007; 57: 881 - 884.
  3. Bingham A, Mamyrova G, Rother KI, Oral E, Cochran E, Premkumar A, Kleiner D, James-Newton L, Targoff IN, Pandey JP, Mercatante Carrick D, Sebring N, O’Hanlon TP, Ruiz Hidalgo M, Turner M, Gordon LB, Laborda J, Bauer SR, Blackshear PJ, Imundo L, Miller FW, Rider LG, for the Childhood Myositis Heterogeneity Study Group. Predictors of Acquired Lipodystrophy in Juvenile-Onset Dermatomyositis and a Gradient of Severity. Medicine.2008; 87: 70- 86.
  4. Mamyrova G., O’Hanlon TP, Sillers L, Malley K, James-Newton L, Parks CG, Cooper GS, Pandey JP, Miller FW, Rider LG, for the Childhood Myositis Heterogeneity Collaborative Study Group. Cytokine Gene Polymorphisms as Risk and Severity Factors for Juvenile Dermatomyositis. Arthritis and Rheumatism. 2008; 58: 3941 - 3950.

Published abstracts:

  1. L. Vegosen, C. Weinberg, T. O'Hanlon, I. Targoff, B. Koneru, G. Mamyrova, F. Miller, L. Rider, and the Childhood Myositis Heterogeneity Study Group. Seasonal Birth Patterns in Subgroups of Myositis Suggest a Role for Perinatal Environmental Factors in Etiology. Arthritis Rheum. 2005; 52 (suppl): S228.
  2. G. Mamyrova, L. Sillers, T. O'Hanlon, J. Pandey, C. Parks, J. Malley, L. James-Newton, C. Wallace, D. Sherry, L. Imundo, C. Lindsley, K. Madson, M. Perez, G. S. Cooper, F. Miller, L. Rider, and the Childhood Myositis Heterogeneity Study Group. Interleukin-1 and Tumor Necrosis Factor Alpha Polymorphisms are Risk and Protective Factors for Juvenile Dermatomyositis (JDM). Arthritis and Rheumatism. 2006; 54 (suppl): S831.
  3. G. Mamyrova, L. Sillers, T. O'Hanlon, J. Pandey, J. Malley, S. Adams, L. James-Newton, C. Wallace, D. Sherry, L. Imundo, C. Lindsley, K. Madson, M. Perez, F. Miller, L. Rider, and the Childhood Myositis Heterogeneity Study Group. Cytokine and HLA Alleles Modulate Disease Severity in Juvenile Dermatomyositis (JDM). Arthritis and Rheumatism. 2006; 54 (suppl): S692-693.
  4. A Bingham, G Mamyrova, E Cochran, E Oral, L James-Newton, A Pokrovnichka, L Imundo, F Miller, L Rider, A Premkumar. MRI Characterization of Regional Fat Loss in Patients with Lipodystrophy Complicating Dermatomyositis. Arthritis and Rheumatism. 2006; 54 (suppl): S169-170.
  5. G. Mamyrova, CA. Bingham, EA Oral, K. Rother, E. Cochran, N. Sebring, J. Pandey, L. James-Newton, T. O'Hanlon, I. Targoff, F. Miller, L. Rider. Clinical and Metabolic Characteristics of Acquired Lipodystrophy in Juvenile Dermatomyositis Arthritis and Rheumatism 2007; 55 (suppl): S145

In July, 2004, Cure JM Foundation also awarded a fellowship to Dr. Kelly Rouster-Stevens, M.D., Pharm. D., for the “Untreated Children with Juvenile Dermatomyositis: Impact of Serologic and Genetic Factors on Bone Mineral Density”. This study is being conducted at Children’s Memorial Research Center in Chicago, and is supervised by Dr. Lauren Pachman, M.D. This fellowship award began July 1, 2004 and will continue through June 30, 2006 for a total of $127,965.