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2015 Cure JM Grant Awards

In keeping with its mission to find better treatments and eventually a cure for Juvenile Myositis, Cure JM Foundation has funded two new grants for researchers. The following researchers were recognized at the 2016 National Conference Awards Dinner:

Dr. YuChack-Yung Yu, D.Phil

Complement C4 in Disease Risk and Pathogenesis of Juvenile Dermatomyositis.

This study will analyze whether variations of C4A genes and changes of C4 proteins can be used to reveal the severity of JDM and how the illness may develop. The research team will analyze hundreds of DNA samples from JDM patients and healthy subjects. They will use cutting-edge techniques to perform experiments -some of the techniques were originally designed by this research team, who are pioneers in the research field of immune genetics. They hope, through their research, to be able to develop better and more specific ways to diagnose and treat the disease, and hopefully to find a cure in the future.

Dr. KimHanna Kim, MD

Novel Biomarkers Associated with Disease Activity in Juvenile Dermatomyositis.

This study will compare and contrast serum markers and gene expression patterns in JDM with those of other closely related disorders (CANDLE and SAVI) with the hopes of better understanding the cause(s) of JDM and possible treatments. The study also intends to identify dysregulated pathways in JDM using RNA-Sequencing to improve biomarkers related to disease activity. By developing a better biomarker, the research team hopes to better predict who will respond to a particular therapy, indicate when to stop and start therapy and develop more JDM-specific therapies in the future.